MTR-106 (MTR106)

Chemical Structure : MTR-106

CAS No.: 1639357-93-9

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货号: PC-26876Not For Human Use, Lab Use Only.

MTR-106 is a highly potent G-quadruplex stabilizer and RNA polymerase I inhibitor, stabilizes G4 sequences and inhibits rRNA synthesis, displays significant antiproliferative activity in homologous recombination repair (HR)-deficient and PARP inhibitor (PARPi)-resistant cancer cells.

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5 mg	￥1480	In stock
10 mg	￥2180	In stock
25 mg	￥3580	In stock
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100 mg		Get quote

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生物&药学活性

MTR-106 is a highly potent G-quadruplex stabilizer and RNA polymerase I inhibitor, stabilizes G4 sequences and inhibits rRNA synthesis, displays significant antiproliferative activity in homologous recombination repair (HR)-deficient and PARP inhibitor (PARPi)-resistant cancer cells.

物理化学性质&存储条件

分子量	525.63
分子式	C28H27N7O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	rel-2-((3aR,6aS)-5-Methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide

参考文献

1. Li MZ, et al. Invest New Drugs. 2021 Oct;39(5):1213-1221.

MTR-106 (MTR106)

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物理化学性质&存储条件

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MTR-106 (MTR106)

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