MTK458 | PINK1 activator | Probechem Biochemicals

Chemical Structure : MTK458

CAS No.: 2499962-58-0

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MTK458 (MTK-458)

货号: PC-49861Not For Human Use, Lab Use Only.

MTK458 (MTK-458) is a potent, selective and brain penetrant PINK1 activator, MTK-458 promotes the first step in mitophagy.

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25 mg	￥2280	In stock
50 mg	￥3780	In stock
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生物&药学活性

MTK458 (MTK-458) is a potent, selective and brain penetrant PINK1 activator, MTK-458 promotes the first step in mitophagy.
MTK458 selectively activates PINK1 by stimulating dimerization and stabilization of the PINK1/TOM complex.
MTK458 binds to PINK1 and stabilizes an active heterocomplex, thereby increasing mitophagy.
MTK458 reduces the PINK1 substrate pS65-Ubiquitin (pUb) in primary neurons and in vivo.
MTK458 drives clearance of pathologic α-synuclein in vitro and in vivo, decreases pS129 α-synuclein aggregates and normalized both brain and corresponding plasma pUb levels in both cellular and animal models of α-synuclein aggregation (PD-like pathology).

物理化学性质&存储条件

分子量	332.33
分子式	C17H15F3N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-6-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

参考文献

1. Chin RM, et al. bioRxiv. 2023 Feb 15:2023.02.14.528378.

MTK458 (MTK-458)

生物&药学活性

物理化学性质&存储条件

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MTK458 (MTK-458)

生物&药学活性

物理化学性质&存储条件

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