MTH1 inhibitor AZ19

Chemical Structure : MTH1 inhibitor AZ19

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货号: PC-20533Not For Human Use, Lab Use Only.

MTH1 inhibitor AZ19 is a highly potent MTH1 inhibitor with IC50 of 0.9 nM and Kd of 0.5 nM, displays EC50 of 7 nM in whole cell thermal stability assay in K562 cells.

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1 g		Get quote

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生物&药学活性

MTH1 inhibitor AZ19 is a highly potent MTH1 inhibitor with IC50 of 0.9 nM and Kd of 0.5 nM, displays EC50 of 7 nM in whole cell thermal stability assay in K562 cells.

物理化学性质&存储条件

分子量	389.81
分子式	C19H17ClFN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C1=C(NC2=CC=C(Cl)C=C2F)C3=CC(OC)=C(OC)C=C3N=C1)NC

参考文献

1. Jason G Kettle, et al. J Med Chem. 2016 Mar 24;59(6):2346-61.