MTDH-SND1 PPI inhibitor C19

Chemical Structure : MTDH-SND1 PPI inhibitor C19

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货号: PC-23758Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

MTDH-SND1 PPI inhibitor C19 is a small-molecule inhibitor of MTDH-SND1 PPI with IC50 of 487 nM, directly binds to the SND1-purified protein, degrades SND1 and downregulates downstream at the protein level.
C19 inhibits breast cancer cell proliferation (MCF-7 cells, IC50=626 nM) and invasion/migration, arrested cell cycle, and induced cell apoptosis.
C19 demonstrated promising inhibitory efficacy for tumor growth in xenograft models

物理化学性质&存储条件

分子量	353.37
分子式	C18H12FN3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-Fluoroquinolin-8-yl)quinoline-8-sulfonamide

参考文献

1. Shen H, et al. J Med Chem. 2025 Jan 10. doi: 10.1021/acs.jmedchem.4c02574.