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MTB-9655

Chemical Structure : MTB-9655

CAS No.: 2332820-04-7

MTB-9655 (MTB9655)

货号: PC-23738Not For Human Use, Lab Use Only.

MTB-9655 is a potent, selective and orally bioavailable Acetyl-Coenzyme A Synthetase 2 (ACSS2) inhibitor with biochemical IC50 of 0.15 nM and EC50 of 3 nM in cellular assays.

规格 价格 库存 数量
5 mg ¥1280 In stock
10 mg ¥1980 In stock
25 mg ¥3480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MTB-9655 is a potent, selective and orally bioavailable Acetyl-Coenzyme A Synthetase 2 (ACSS2) inhibitor with biochemical IC50 of 0.15 nM and EC50 of 3 nM in cellular assays.
MTB-9655 induces anti-tumor effects in xenograft mouse models of human colorectal, breast and lung cancers that express high levels of ACSS2.

物理化学性质&存储条件

分子量 415.40
分子式 C21H19F2N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzoic acid, 3-[4-[[[3-(1,1-difluoroethyl)phenyl]amino]carbonyl]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-, methyl ester

参考文献

1. Ruth Perets, et al. Journal of Clinical Oncology Volume 40, Number 16_suppl, 2022 ASCO Annual Meeting I

2. Andreas Goutopoulos, et al.Cancer Res (2022) 82 (12_Supplement): 2326.

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