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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-MT16-001
MT16-001

Chemical Structure : MT16-001

CAS No.: 1895049-73-6

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MT16-001 (MT 16-001)

货号: PC-72699Not For Human Use, Lab Use Only.

MT16-001 is a selective, covalent inhibitor of deubiquitinating enzyme UCHL1 with IC50 of 580 nM, no inhibitory effect against UCHL3 (IC50>30 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MT16-001 is a selective, covalent inhibitor of deubiquitinating enzyme UCHL1 with IC50 of 580 nM, no inhibitory effect against UCHL3 (IC50>30 uM).
    MT16-001 inhibits structurally unrelated DUB USP30 with similar potency.
    MT16-001 showed cytotoxicity in human embryonic kidney cells (HEK293) with EC50 of 730 nM, effectively engaged UCHL1 in cells with EC50 of 550 nM.
    MT16-001 showed excellent selectivity for UCHL1 across the UCH family: UCHL1, UCHL3, UCHL5 and BAP1.

    物理化学性质&存储条件

    分子量 298.364
    分子式 C15H14N4OS
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-1-cyano-N-(5-phenylthiazol-2-yl)pyrrolidine-3-carboxamide

    参考文献

    1. Nattawadee Panyain, et al. RSC Med Chem. 2021 Aug 16;12(11):1935-1943.

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