MT-7716 |CAS:1215859-93-0 Probechem Biochemicals

Chemical Structure : MT-7716

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MT-7716 (MT7716, W212393 hydrochloride)

货号: PC-61542Not For Human Use, Lab Use Only.

A highly potent, brain-penetrating ORL1 receptor (NOP receptor) agonist with Ki of 0.76 and 0.50 nM for rat and human ORL1 receptors, respectively.

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生物&药学活性

MT-7716 (W212393 hydrochloride) is a highly potent, brain-penetrating ORL1 receptor (NOP receptor) agonist with Ki of 0.76 and 0.50 nM for rat and human ORL1 receptors, respectively.
MT-7716 displays a relative selectivity over μ receptor and serotonin transporters.
MT-7716 significantly suppresses the activity of spontaneously firing rat suprachiasmatic nucleus neurons at 100 nM.
MT-7716 induces a significant phase advance at circadian time 6 (CT6) and CT9, but not at other CTs, represents an interesting agent for the study of circadian rhythms.
MT-7716 dose-dependently decreases GABAergic transmission and effectively blocks the ethanol-induced increase in GABA release at these synapses.

物理化学性质&存储条件

分子量	477.005
分子式	C27H29ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide hydrochloride

参考文献

1. Teshima K, et al. Br J Pharmacol. 2005 Sep;146(1):33-40.

2. Miyakawa K, et al. Neuropharmacology. 2007 Mar;52(3):1055-64.

3. Kallupi M, et al. Front Integr Neurosci. 2014 Feb 18;8:18.

MT-7716 (MT7716, W212393 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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MT-7716 (MT7716, W212393 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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