MT-228 | non-muscle myosin II inhibitor | Probechem Biochemicals

Chemical Structure : MT-228

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MT-228 (MT228)

货号: PC-23211Not For Human Use, Lab Use Only.

MT-228 is a potent, selective, first-in-class non-muscle myosin II (NMII) inhibitor with Ki of 1.5 uM and cytokinesis EC50 of 1.0 uM, 17-fold selectivity for NMII over cardiac myosin II (CMII).

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生物&药学活性

MT-228 is a potent, selective, first-in-class non-muscle myosin II (NMII) inhibitor with Ki of 1.5 uM and cytokinesis EC50 of 1.0 uM, 17-fold selectivity for NMII over cardiac myosin II (CMII).
MT-228 has improved cardiac safety and selectivity compared to Blebbistatin.
MT-228's brain penetrance was also significantly improved over Blebbistatin.
MT-228 is a four-fold more potent inhibitor of SmMII (KI = 4.0 µM) than CMII (KI = 17.0 µM).
MT-228 (0.5 mg/kg) produces a selective disruption of the motivation in METH-associated CPP in mice, without impacting other brain processes.

物理化学性质&存储条件

分子量	337.38
分子式	C19H19N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3a-hydroxy-1-(2-methoxypyridin-4-yl)-6,7-dimethyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one

参考文献

1. Radnai L, et al. bioRxiv [Preprint]. 2024 Oct 12:2024.10.07.617018.

MT-228 (MT228)

生物&药学活性

物理化学性质&存储条件

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MT-228 (MT228)

生物&药学活性

物理化学性质&存储条件

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