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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Myosin-MT-134
MT-134

Chemical Structure : MT-134

CAS No.: 2968308-52-1

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MT-134 (Skeletostatin MT-134)

货号: PC-72702Not For Human Use, Lab Use Only.

MT-134 (Skeletostatin MT-134) is a selective skeletal myosin II (SkMII) inhibitor with Ki of 0.48 uM, 40- to 170-fold for SkMII over all other myosin II family members.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MT-134 (Skeletostatin MT-134) is a selective skeletal myosin II (SkMII) inhibitor with Ki of 0.48 uM, 40- to 170-fold for SkMII over all other myosin II family members.
    MT-134 showed excellent in vivo tolerability, efficacy, and pharmacokinetics.
    MT-134 was well-tolerated in mice, impaired motor performance, and had excellent exposure in muscles.

    物理化学性质&存储条件

    分子量 348.362
    分子式 C19H16N4O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-3a-Hydroxy-6-methyl-1-(2-methyloxazolo[4,5-b]pyridin-6-yl)-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one

    参考文献

    1. Laszlo Radnai, et al. ACS Chem Biol. 2021 Nov 19;16(11):2164-2173.

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