MT-1207 hydrochloride | α1/5-HT2A antagonist | Probechem Biochemicals

Chemical Structure : MT-1207 hydrochloride

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MT-1207 hydrochloride (MT1207 hydrochloride)

货号: PC-22599Not For Human Use, Lab Use Only.

MT-1027 hydrochloride is a highly potent α1 adrenoceptor and 5-HT2A receptor antagonist with IC50 of <0.1 nM and 0.27 nM respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MT-1027 hydrochloride is a highly potent α1 adrenoceptor and 5-HT2A receptor antagonist with IC50 of <0.1 nM and 0.27 nM respectively.
MT-1027 also shows high potency against adrenergic α1B (IC50 = 0.15 nM and Ki = 0.086 nM) and for adrenergic α1D (IC50 = 1.40 nM and Ki = 0.69 nM).
MT-1027 shows pA2 values of 7.98 ± 0.04 and 8.86 against noradrenaline and 5-HT-induced contraction in aortae.
MT-1027 has fewer side effects in a postural BP assay and could prevent the onset of postural hypotension.

物理化学性质&存储条件

分子量	428.98
分子式	C21H25ClN6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-(4-(1H-benzo[d][1,2,3]triazol-1-yl)butyl)piperazin-1-yl)benzo[d]isothiazole hydrochloride

参考文献

1. Wang P, et al. J Med Chem. 2024 Jul 5. doi: 10.1021/acs.jmedchem.4c00626.

2. Xu TY, et al. Acta Pharmacol Sin. 2021 Jun;42(6):885-897.

MT-1207 hydrochloride (MT1207 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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MT-1207 hydrochloride (MT1207 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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