MT-1207 | α1/5-HT2A antagonist | Probechem Biochemicals

Chemical Structure : MT-1207

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MT-1207 (MT1207)

货号: PC-22598Not For Human Use, Lab Use Only.

MT-1027 is a highly potent α1 adrenoceptor and 5-HT2A receptor antagonist with IC50 of <0.1 nM and 0.27 nM respectively.

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生物&药学活性

MT-1027 is a highly potent α1 adrenoceptor and 5-HT2A receptor antagonist with IC50 of <0.1 nM and 0.27 nM respectively.
MT-1027 also shows high potency against adrenergic α1B (IC50 = 0.15 nM and Ki = 0.086 nM) and for adrenergic α1D (IC50 = 1.40 nM and Ki = 0.69 nM).
MT-1027 shows pA2 values of 7.98 ± 0.04 and 8.86 against noradrenaline and 5-HT-induced contraction in aortae.
MT-1027 has fewer side effects in a postural BP assay and could prevent the onset of postural hypotension.

物理化学性质&存储条件

分子量	392.53
分子式	C21H24N6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-(4-(1H-Benzotriazole-1-yl)butyl)piperazine-1-yl)benzisothiazole

参考文献

1. Wang P, et al. J Med Chem. 2024 Jul 5. doi: 10.1021/acs.jmedchem.4c00626.

2. Xu TY, et al. Acta Pharmacol Sin. 2021 Jun;42(6):885-897.

MT-1207 (MT1207)

生物&药学活性

物理化学性质&存储条件

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MT-1207 (MT1207)

生物&药学活性

物理化学性质&存储条件

参考文献

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