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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-MSX-122
MSX-122

Chemical Structure : MSX-122

CAS No.: 897657-95-3

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MSX-122 (MSX122)

货号: PC-38724Not For Human Use, Lab Use Only.

MSX-122 is a small molecule and partial CXCR4 antagonist, directly binds to the CXCL12 site on CXCR4 and inhibits CXCR4/CXCL12 actions with IC50 of 10 nM.

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10 mg ￥880 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MSX-122 is a small molecule and partial CXCR4 antagonist, directly binds to the CXCL12 site on CXCR4 and inhibits CXCR4/CXCL12 actions with IC50 of 10 nM.
MSX-122 (100 nM) effectively blocked invasion of 78% MDA-MB-231 cells while the same concentration of AMD3100 blocked invasion of 62% cells.
MSX-122 exhibits a different profile than AMD3100 and other reported anti-CXCR4 compounds: (1) MSX-122 did not inhibit T-tropic HIV infection (via the formation of the CXCR4/CD4/GP120 complex), while AMD3100; (2) unlike AMD3100, MSX-122 proved to be inactive in our calcium flux assay.
MSX-122 attenuates colonic damage in mice with experimental colitis, inhibits inflammation induced by carrageenan and lung fibrosis induced by bleomycin.
MSX-122 blocks metastasis in an experimental animal model of breast cancer metastasis, also inhibit metastatic progression in an orthotopic mouse model of uveal melanoma micrometastasis.

物理化学性质&存储条件

分子量 292.346
分子式 C16H16N6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N,N'-(1,4-phenylenebis(methylene))dipyrimidin-2-amine

参考文献

1. Liang Z, et al. PLoS One. 2012;7(4):e34038.

2. Shu HK, et al. PLoS One. 2013 Nov 7;8(11):e79768.

3. Wu X, et al. Cancer Sci. 2022 Mar;113(3):926-939.

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