MSU38225 | Nrf2 inhibitor | Probechem Biochemicals

Chemical Structure : MSU38225

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MSU38225 (MSU 38225, MSU-38225)

货号: PC-38190Not For Human Use, Lab Use Only.

MSU38225 (MSU-38225) is a novel small molecule that inhibit the Nrf2 pathway, potentially inhibiting Nrf2 transcriptional activity and cancer cell growth.

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生物&药学活性

MSU38225 (MSU-38225) is a novel small molecule that inhibit the Nrf2 pathway, potentially inhibiting Nrf2 transcriptional activity and cancer cell growth.
MSU38225 downregulates Nrf2 transcriptional activity and decreases the expression of Nrf2 downstream targets, including NQO1, GCLC, GCLM, AKR1C2, and UGT1A6.
MSU38225 strikingly decreases the protein level of Nrf2, which can be blocked by the proteasome inhibitor MG132.
Ubiquitination of Nrf2 is enhanced following treatment with MSU38225.
By inhibiting production of antioxidants, MSU38225 increases the level of reactive oxygen species (ROS) when cells are stimulated with tert-butyl hydroperoxide (tBHP).
MSU38225 also inhibits the growth of human lung cancer cells in both two-dimensional cell culture and soft agar.

物理化学性质&存储条件

分子量	313.404
分子式	C21H19N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO (3.1 mg/mL)
Chemical Name/SMILES	2-[(3,5-Dimethylphenyl)amino]-6-methyl-5-phenyl-3-pyridinecarbonitrile

参考文献

1. Di Zhang, et al. Mol Cancer Ther. 2021 Sep;20(9):1692-1701.

MSU38225 (MSU 38225, MSU-38225)

生物&药学活性

物理化学性质&存储条件

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MSU38225 (MSU 38225, MSU-38225)

生物&药学活性

物理化学性质&存储条件

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