MST3/4 inhibitor MR30

Chemical Structure : MST3/4 inhibitor MR30

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货号: PC-21862Not For Human Use, Lab Use Only.

MST3/4 inhibitor MR30 is a potent, selective STE20-like (MST3/4) kinase inhibitor with IC50 of 178 nM and 1100 nM for MST3 and MST4, respectively.

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生物&药学活性

MST3/4 inhibitor MR30 is a potent, selective STE20-like (MST3/4) kinase inhibitor with IC50 of 178 nM and 1100 nM for MST3 and MST4, respectively.
MR30 does not inhibit MST1/2, and selectivity score with 8/100 kinases, also only weakly binds to NEK2, CK1e, and FES, with EC50 values in the micromolar range
MR30 increases the fraction of cells in the G1 phase at 10 μM in HCT116 cells.
MR30 inhibits Hippo signaling pathway and mitotic cell-cycle progression.

物理化学性质&存储条件

分子量	560.10
分子式	C30H34ClN7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-(4-Aminobutyl)-6-(2-chloro-4-(6-methylpyridin-2-yl)phenyl)-2-((3-(2-oxopyrrolidin-1-yl)propyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

参考文献

1. Marcel Rak, et al. J Med Chem. 2024 Feb 29. doi: 10.1021/acs.jmedchem.3c02217.