MST3/4 inhibitor MR24

Chemical Structure : MST3/4 inhibitor MR24

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货号: PC-21861Not For Human Use, Lab Use Only.

MST3/4 inhibitor MR24 is a potent, selective STE20-like (MST3/4) kinase inhibitor with IC50 of 57 nM and 583 nM for MST3 and MST4, respectively.

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生物&药学活性

MST3/4 inhibitor MR24 is a potent, selective STE20-like (MST3/4) kinase inhibitor with IC50 of 57 nM and 583 nM for MST3 and MST4, respectively.
MR24 does not inhibit MST1/2, and selectivity score with 8/100 kinases, also only weakly binds to NEK2, CK1e, and FES, with EC50 values in the micromolar range
MR24 increases the fraction of cells in the G1 phase at 10 μM in HCT116 cells.
MR24 inhibits Hippo signaling pathway and mitotic cell-cycle progression.

物理化学性质&存储条件

分子量	509.01
分子式	C26H29ClN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-(4-Aminobutyl)-6-(2-chloro-4-(6-methylpyridin-2-yl)phenyl)-2-((1,3-dihydroxypropan-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

参考文献

1. Marcel Rak, et al. J Med Chem. 2024 Feb 29. doi: 10.1021/acs.jmedchem.3c02217.