MSI-1436 |CAS:186139-09-3 Probechem Biochemicals

Chemical Structure : MSI-1436

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MSI-1436 (Trodusquemine;Aminosterol-1436;MSI1436)

货号: PC-42921Not For Human Use, Lab Use Only.

MSI-1436 (Trodusquemine) is an non-competitive, allosteric inhibitor of PTP1B with Ki of 0.6 uM for PTP1B 1-405.

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生物&药学活性

MSI-1436 (Trodusquemine) is an non-competitive, allosteric inhibitor of PTP1B with Ki of 0.6 uM for PTP1B 1-405.
MSI-1436 antagonizes HER2 signaling, inhibits tumorigenesis in xenografts and abrogates metastasis in the NDL2 mouse model of breast cancer.

物理化学性质&存储条件

分子量	685.0564
分子式	C37H72N4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cholestane-7,24-diol, 3-[[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]amino]-, 24-(hydrogen sulfate), (3β,5α,7α,24R)-

参考文献

1. Krishnan N, et al. Nat Chem Biol. 2014 Jul;10(7):558-66.

2. Qin Z, et al. Biochem Biophys Res Commun. 2015 Feb 27;458(1):21-7.

MSI-1436 (Trodusquemine;Aminosterol-1436;MSI1436)

生物&药学活性

物理化学性质&存储条件

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MSI-1436 (Trodusquemine;Aminosterol-1436;MSI1436)

生物&药学活性

物理化学性质&存储条件

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