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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-PPAR-MSDC0160
MSDC0160

Chemical Structure : MSDC0160

CAS No.: 146062-49-9

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MSDC0160 (Mitoglitazone, MSDC-0160)

货号: PC-73019Not For Human Use, Lab Use Only.

MSDC0160 (Mitoglitazone, MSDC-0160) is a small molecule targeting mitochondrial pyruvate carrier (MPC), also is an insulin sensitizer with anti-diabetes activities.

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10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3680 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MSDC0160 (Mitoglitazone, MSDC-0160) is a small molecule targeting mitochondrial pyruvate carrier (MPC), also is an insulin sensitizer with anti-diabetes activities.
MSDC0160 exhibited glucose-lowering effects similar to those of pioglitazone but without the adverse effects associated with PPAR-γ agonists.
MSDC0160 has low affinity for binding and activation of PPARγ and has insulin-sensitizing effects in mouse models of diabetes.
MSDC0160 increased AMPK activity and reduced mTOR activity in human islets.
MSDC-0160 in combination with IGF-1 and 8 mM glucose increased β-cell specific gene expression of insulin, pdx1, nkx6.1, and nkx2.2, and maintained insulin content without altering glucose-stimulated insulin secretion.
MSDC0160 suppresses tumor growth in preclinical models of AR-driven PCa.

物理化学性质&存储条件

分子量 370.423
分子式 C19H18N2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-[[4-[2-(5-ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione

参考文献

1. Bader DA, et al. Nat Metab. 2019 Jan;1(1):70-85.

2. Shah RC, et al. Curr Alzheimer Res. 2014;11(6):564-73.

3. Colca JR, et al. Clin Pharmacol Ther. 2013 Apr;93(4):352-9.

4. Rohatgi N, et al. PLoS One. 2013 May 1;8(5):e62012.

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