MSDC-0602K |CAS:1314533-27-1 Probechem Biochemicals

Chemical Structure : MSDC-0602K

CAS No.: 1314533-27-1

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MSDC-0602K (Azemiglitazone potassium)

货号: PC-38092Not For Human Use, Lab Use Only.

MSDC-0602K (Azemiglitazone) is a PPARγ-sparing thiazolidinedione insulin sensitizer, targets mitochondrial pyruvate carrier protein (MPC) Mpc1 and Mpc2.

规格	价格	库存
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg	￥5480	In stock
500 mg	￥9880	In stock
1 g		Get quote

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生物&药学活性

MSDC-0602K (Azemiglitazone) is a PPARγ-sparing thiazolidinedione insulin sensitizer, targets mitochondrial pyruvate carrier protein (MPC) Mpc1 and Mpc2; MSDC-0602 prevented and reversed liver fibrosis and suppressed expression of markers of stellate cell activation in livers of mice fed a diet rich in trans-fatty acids, fructose, and cholesterol. MSDC-0602 directly reduced hepatic stellate cell activation in vitro. MSDC-0602 treatment or hepatocyte MPC2 deletion also limited stellate cell activation indirectly by affecting secretion of exosomes from hepatocytes.

物理化学性质&存储条件

分子量	409.497
分子式	C19H16KNO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-Thiazolidinedione, 5-((4-(2-(3-methoxyphenyl)-2-oxoethoxy)phenyl)methyl)-, potassium salt (1:1)

参考文献

1. Colca JR, et al. PLoS One. 2013 May 15;8(5):e61551.

2. Fukunaga T, et al. J Bone Miner Res. 2015 Mar;30(3):481-8.

3. McCommis KS, et al. Hepatology. 2017 May;65(5):1543-1556.

MSDC-0602K (Azemiglitazone potassium)

生物&药学活性

物理化学性质&存储条件

参考文献

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MSDC-0602K (Azemiglitazone potassium)

生物&药学活性

物理化学性质&存储条件

参考文献

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