MSD199 | Nav1.8 inhibitor | Probechem Biochemicals

Chemical Structure : MSD199

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MSD199 (MSD-199)

货号: PC-23138Not For Human Use, Lab Use Only.

MSD199 is a potent, and selective Nav1.8 inhibitor with IC50 of 4.7 nM in Qube automated patch-clamp assay, >2000-fold selective over all other Nav isoforms.

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生物&药学活性

MSD199 is a potent, and selective Nav1.8 inhibitor with IC50 of 4.7 nM in Qube automated patch-clamp assay, >2000-fold selective over all other Nav isoforms.
MSD199 (1, 3, and 10 mg/kg) dose-dependently reduced capsaicin-sensitized thermode (CST) response count.
MSD199 (1.3 mg/kg IV) dose-dependently prevented capsaicin flare propagation in vivo.
MSD199 (1.3 mg/kg) significantly reduced flare size at 1400 mA diode laser stimulation.

物理化学性质&存储条件

分子量	425.45
分子式	C18H21F2N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4,4-difluoroazepan-1-yl)-6-methyl-N-(2-sulfamoylpyridin-4-yl)nicotinamide

参考文献

1. Vardigan JD, et al. Pain. 2024 Oct 8. doi: 10.1097/j.pain.0000000000003404.

MSD199 (MSD-199)

生物&药学活性

物理化学性质&存储条件

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MSD199 (MSD-199)

生物&药学活性

物理化学性质&存储条件

参考文献

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