MSC2530818 | CDK8 inhibitor | Probechem Biochemicals

Chemical Structure : MSC2530818

CAS No.: 1883423-59-3

加入收藏

MSC2530818 (MSC 2530818;MSC-2530818)

货号: PC-60298Not For Human Use, Lab Use Only.

MSC-2530818 (MSC 2530818, MSC2530818) is a potent, selective, and orally bioavailable CDK8 inhibitor with IC50 of 2.6 nM.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg	￥4580	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

MSC2530818 (MSC 2530818, MSC-2530818) is a potent, selective, and orally bioavailable CDK8 inhibitor with IC50 of 2.6 nM.
MSC2530818 binds to CDK8 and CDK19 with similar affinity (4 nM), and displays good selectivity profile in a 264 kinase panel with exception of GSK3α (IC50=691 nM).
MSC2530818 potently inhibits of phospho-STAT1 S727 in SW620 cells (IC50=8 nM), shows potent inhibition of WNT-dependent transcription in human cancer cell lines.
MSC2530818 demonstrates tumor growth inhibition in an APC mutant SW620 human colorectal carcinoma xenograft model.

物理化学性质&存储条件

分子量	340.811
分子式	C18H17ClN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone

参考文献

1. Czodrowski P, et al. J Med Chem. 2016 Oct 27;59(20):9337-9349.

MSC2530818 (MSC 2530818;MSC-2530818)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

MSC2530818 (MSC 2530818;MSC-2530818)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.