MSC 1094308 |CAS:2219320-08-6 Probechem Biochemicals

Chemical Structure : MSC 1094308

CAS No.: 2219320-08-6

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MSC 1094308 (MSC1094308)

货号: PC-62542Not For Human Use, Lab Use Only.

MSC1094308 (MSC 1094308) is a reversible, allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B with IC50 of 7.2 and 0.71 uM, respectively.

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10 mg	￥1580	In stock
25 mg	￥2680	In stock
50 mg	￥4580	In stock
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生物&药学活性

MSC1094308 (MSC 1094308) is a reversible, allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B with IC50 of 7.2 and 0.71 uM, respectively.
MSC1094308 binds to drugable hotspot of p97, thereby inhibiting the D2 ATPase activity.
MSC1094308 is active in cells, and specifically inhibits p97 but not the proteasome.

物理化学性质&存储条件

分子量	462.56
分子式	C29H29F3N2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl)-4,4-bis(4-fluorophenyl)butan-1-amine

参考文献

1. Pöhler R, et al. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1576-1580.

MSC 1094308 (MSC1094308)

生物&药学活性

物理化学性质&存储条件

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MSC 1094308 (MSC1094308)

生物&药学活性

物理化学性质&存储条件

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