MSC-5046 | TEAD1 inhibitor | Probechem Biochemicals

Chemical Structure : MSC-5046

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MSC-5046 (MSC5046)

货号: PC-23231Not For Human Use, Lab Use Only.

MSC-5046 is a potent, selective, reversible TEAD1 inhibitor with EC50 of 58 nM in TEAD-reporter assay in SK-Hep-1 cells, shows viability affect in NCI-H226 cell line with EC50 of 12 nM.

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生物&药学活性

MSC-5046 is a potent, selective, reversible TEAD1 inhibitor with EC50 of 58 nM in TEAD-reporter assay in SK-Hep-1 cells, shows viability affect in NCI-H226 cell line with EC50 of 12 nM.
MSC-5046 shows cellular palmitoylation inhibition of TEAD1 in HEK-293 cells, but not TEAD2, TEAD3 and TEAD4.
MSC-5046 has a favourable in vitro profile in a suite of cellular assays with a good correlation between TEAD-reporter, on-target NCI-H226 viability and TEAD regulated target gene Cyr61 biomarker modulation in both NCI-H226 and SK-HEP-1 cell lines.

物理化学性质&存储条件

分子量	481.44
分子式	C24H18F3N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(acrylamidomethyl)-3-fluoro-4-(4-fluorophenoxy)benzyl)-6-fluoroimidazo[1,2-a]pyrimidine-3-carboxamide

参考文献

1. Carswell E, et al. Bioorg Med Chem Lett. 2024 Oct 4:129981.

MSC-5046 (MSC5046)

生物&药学活性

物理化学性质&存储条件

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MSC-5046 (MSC5046)

生物&药学活性

物理化学性质&存储条件

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