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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Monocarboxylate Transporter (MCT)-MSC-4381
MSC-4381

Chemical Structure : MSC-4381

CAS No.: 2445185-57-7

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MSC-4381 (MCT4 inhibitor 18n)

货号: PC-72709Not For Human Use, Lab Use Only.

MSC-4381 (MCT4 inhibitor 18n) is a potent, selective inhibitor of monocarboxylate transporter 4 (MCT4/SLC16A3).

规格 价格 库存 数量
5 mg ￥2980 In stock
10 mg ￥4880 In stock
25 mg ￥7980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MSC-4381 (MCT4 inhibitor 18n) is a potent, selective inhibitor of monocarboxylate transporter 4 (MCT4/SLC16A3).
In vitro treatment with 18n resulted in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells.
MCT4 inhibitor 18n demonstrated lactate modulation and antitumor activity in a mouse tumor model.

物理化学性质&存储条件

分子量 537.971
分子式 C26H20ClN3O6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-((5-chloro-2-((5-ethoxyquinoline)-8-sulfonamido)phenyl)ethynyl)-4-methoxypicolinic acid

参考文献

1. Timo Heinrich, et al. J Med Chem. 2021 Aug 26;64(16):11904-11933.

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