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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-YAP-TEAD-MSC-1254
MSC-1254

Chemical Structure : MSC-1254

CAS No.:

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MSC-1254 (MSC1254)

货号: PC-23232Not For Human Use, Lab Use Only.

MSC-1254 is a potent, selective, reversible TEAD1 inhibitor with EC50 of 1 uM in TEAD-reporter assay in SK-Hep-1 cells, shows viability affect in NCI-H226 cell line with EC50 of 0.04 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MSC-1254 is a potent, selective, reversible TEAD1 inhibitor with EC50 of 0.1 uM in TEAD-reporter assay in SK-Hep-1 cells, shows viability affect in NCI-H226 cell line with EC50 of 0.04 uM.
MSC-1254 shows cellular palmitoylation inhibition of TEAD1 in HEK-293 cells, but not TEAD2, TEAD3 and TEAD4.

物理化学性质&存储条件

分子量 512.53
分子式 C25H22F2N4O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-(1,1-dioxidothiomorpholino)-4-(4-fluorophenoxy)benzyl)-6-fluoroimidazo[1,2-a]pyridine-3-carboxamide

参考文献

1. Carswell E, et al. Bioorg Med Chem Lett. 2024 Oct 4:129981.

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