MS9024

Chemical Structure : MS9024

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货号: PC-24065Not For Human Use, Lab Use Only.

MS9024 is a potent, selective PROTAC degrader of DNA methyltransferase 1 (DNMT1) with DC50 of 40 nM in HCT116 cells, Dmax=89%.

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生物&药学活性

MS9024 is a potent, selective PROTAC degrader of DNA methyltransferase 1 (DNMT1) with DC50 of 40 nM in HCT116 cells, Dmax=89%.
MS9024 potently induces DNMT1 degradation in colorectal cancer (CRC), breast cancer (BC), and non-small-cell lung cancer (NSCLC) cells.
MS9024 selectively induced DNMT1 degradation in a concentration-, time-, and ubiquitin–proteasome system (UPS)-dependent manner without affecting DNMT1 transcription.
MS9024 potently degraded DNMT1 without altering the mRNA expression of DNMT1 in BC and NSCLC cells.

物理化学性质&存储条件

分子量	422.51
分子式	C21H22N6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((6-((2-Amino-2-oxo-1-phenylethyl)thio)-3,5-dicyano-4-ethylpyridin-2-yl)(methyl)amino)-N-methylacetamide

参考文献

1. Qian C, et al. J Med Chem. 2025 Feb 5. doi: 10.1021/acs.jmedchem.4c02161.

MS9024

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物理化学性质&存储条件

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MS9024

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物理化学性质&存储条件

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