MS417 |CAS:916489-36-6 Probechem Biochemicals

Chemical Structure : MS417

CAS No.: 916489-36-6

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MS417 (GTPL-7512, MS-417)

货号: PC-62474Not For Human Use, Lab Use Only.

MS417 (GTPL-7512) is a highly specific BET bromodomain inhibitor that binds to BRD4-BD1 and BRD4 BD2 with Kd of 36.1 uM and 25.4 uM respectively.

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10 mg	￥1480	In stock
25 mg	￥2580	In stock
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生物&药学活性

MS417 (GTPL-7512) is a highly specific BET bromodomain inhibitor that binds to BRD4-BD1 and BRD4 BD2 with Kd of 36.1 uM and 25.4 uM respectively.
MS417 shows 100-200-fold weaker affinity for CBP, BRD7, or BPTF, and no binding affinity for many other bromodomains.
MS417 blocks BRD4 binding to the acetylated NF-κB, effectively attenuates NF-κB transcriptional activation of proinflammatory genes in kidney cells treated with TNFα or infected by HIV.
MS417 ameliorates inflammation and kidney injury in HIV-1 transgenic mice.

物理化学性质&存储条件

分子量	414.908
分子式	C20H19ClN4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl 2-[(6S,Z)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate

参考文献

1. Zhang G, et al. J Biol Chem. 2012 Aug 17;287(34):28840-51.

2. Boehm D, et al. Cell Cycle. 2013 Feb 1;12(3):452-62.

MS417 (GTPL-7512, MS-417)

生物&药学活性

物理化学性质&存储条件

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MS417 (GTPL-7512, MS-417)

生物&药学活性

物理化学性质&存储条件

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