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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-MS4138
MS4138

Chemical Structure : MS4138

CAS No.:

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MS4138 (MS-4138)

货号: PC-26273Not For Human Use, Lab Use Only.

MS4138 is a potent, selective and covalent inhibitor of protein lysine methyltransferase (PKMT) SETD8 with IC50 of 1.4 uM, covalently modifies SETD8 at Cys311.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MS4138 is a potent, selective and covalent inhibitor of protein lysine methyltransferase (PKMT) SETD8 with IC50 of 1.4 uM, covalently modifies SETD8 at Cys311.

物理化学性质&存储条件

分子量 414.51
分子式 C21H30N6O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-((7-(2-aminoethoxy)-6-methoxy-2-(pyrrolidin-1-yl)quinazolin-4-yl)amino)propyl)acrylamide

参考文献

1. Shi Chen, et al. Elife. 2019 May 13:8:e45403.

2. Patent WO2015172076A1.

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