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首页-小分子抑制剂&激动剂-Others-Other Targets-MS37452
MS37452

Chemical Structure : MS37452

CAS No.: 423748-02-1

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MS37452 (MS 37452)

货号: PC-62651Not For Human Use, Lab Use Only.

MS-37452 is a small-molecule modulator of methyl-lysine binding for CBX7 chromodomain.

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5 mg ￥1280 In stock
10 mg ￥1880 In stock
25 mg ￥2980 In stock
50 mg ￥4980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MS37452 is a small-molecule modulator of methyl-lysine binding for CBX7 chromodomain, disrupts CBX7-H3K27me3 and H3K9me3 binding with Ki of 43.0 and 55.3 uM, respectively
MS37452 derepresses transcription of Polycomb repressive complex target gene p16/CDKN2A by displacing CBX7 binding to the INK4A/ARF locus in prostate cancer cells.
MS37452 disrupts CBX7 binding to the INK4A/ARF locus, subsequently resulting in transcriptional de-repression of its target genes p14/ARF and p16/INK4a in PC3 cells.

物理化学性质&存储条件

分子量 398.459
分子式 C22H26N2O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(2,3-Dimethoxybenzoyl)-4-[(3-methylphenoxy)acetyl]-piperazine

参考文献

1. Ren C, et al. Chem Biol. 2015 Feb 19;22(2):161-8.

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