MS21570 | GPR171 antagonist | Probechem Biochemicals

Chemical Structure : MS21570

CAS No.: 65373-29-7

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MS21570 (MS0021570, MS 21570)

货号: PC-49001Not For Human Use, Lab Use Only.

MS 21570 (MS0021570) is a small molecule antagonist of GPR171, antagonizes MS0015203 (Cat#PC-47110)-mediated increases in [35S]GTPγS binding in rat hypothalamic membranes (EC50 =0.6 nM).

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25 mg	￥1480	In stock
50 mg	￥2480	In stock
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生物&药学活性

MS 21570 (MS0021570) is a small molecule antagonist of GPR171, antagonizes MS0015203 (Cat#PC-47110)-mediated increases in [35S]GTPγS binding in rat hypothalamic membranes (EC50 =0.6 nM).
MS 21570 blocked BigLEN-mediated activation of GPR171 in heterologous cells.
MS 21570 inhibited BigLEN-mediated hyperpolarization of BLA pyramidal neurons.
MS 21570 inhibited feeding induced by DREADD-mediated activation of BigLEN containing AgRP neurons in the arcuate nucleus.
MS 21570 significantly attenuated BigLEN-mediated decreases in intracellular cAMP levels.
MS 21570 (5 mg/kg, i.p) decreases anxiety-like behaviors, but not depression and fear in vivo.

物理化学性质&存储条件

分子量	237.35
分子式	C10H11N3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(benzylthio)-N-methyl-1,3,4-thiadiazol-2-amine

参考文献

1. Erin N Bobeck, et al. Neuropsychopharmacology. 2017 Dec;42(13):2527-2536.

MS21570 (MS0021570, MS 21570)

生物&药学活性

物理化学性质&存储条件

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MS21570 (MS0021570, MS 21570)

生物&药学活性

物理化学性质&存储条件

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