MS167 | PRMT6 inhibitor | Probechem Biochemicals

Chemical Structure : MS167

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MS167 (MS-167)

货号: PC-23079Not For Human Use, Lab Use Only.

MS167 is a potent, selective and cell-active reversible PRMT6 inhibitor with IC50 of 28 nM.

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生物&药学活性

MS167 is a potent, selective and cell-active reversible PRMT6 inhibitor with IC50 of 28 nM.
MS167 does not inhibit other closely related PRMTs and was selective for PRMT6 over other methyltransferases.
MS167 potently and concentration-dependently reduces cellular levels of H3R2 asymmetric dimethylation (H3R2me2a, IC50=6.7 uM) against ectopically expressed PRMT6 in HEK293 cells.
MS167 is not cytotoxic in MCF-7, PNT2, and HEK293T cells.

物理化学性质&存储条件

分子量	300.41
分子式	C17H24N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(4-(((2-aminoethyl)(methyl)amino)methyl)-1H-pyrrol-3-yl)phenyl)propionamide

参考文献

1. Shen Y, et al. J Med Chem. 2020 May 28;63(10):5477-5487.

MS167 (MS-167)

生物&药学活性

物理化学性质&存储条件

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MS167 (MS-167)

生物&药学活性

物理化学性质&存储条件

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