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首页-小分子抑制剂&激动剂-Others-Other Targets-MS0621
MS0621

Chemical Structure : MS0621

CAS No.: 2031251-11-1

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MS0621 (MS 0621, UNC0621)

货号: PC-49739Not For Human Use, Lab Use Only.

MS0621 (UNC0621, MS 0621) is a small-molecule modulator of EWSR1::FLI1-mediated chromatin, reverses EWSR1::FLI1-mediated chromatin accessibility, persistently and selectively inhibits cell proliferation in Ewing sarcoma cell lines (SK-N-MC, IC50=128 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MS0621 (UNC0621, MS 0621) is a small-molecule modulator of EWSR1::FLI1-mediated chromatin, reverses EWSR1::FLI1-mediated chromatin accessibility, persistently and selectively inhibits cell proliferation in Ewing sarcoma cell lines (SK-N-MC, IC50=128 nM).
    MS0621 displays no activity against clear cell sarcoma cell line with the oncogenic EWS::ATF1 rearrangement (SU-CCS-1), and two primary cell lines that either express FLI1 (HUVEC) or do not express FLI1 (RPTEC).
    MS0621 induces a G1/S arrest in Ewing sarcoma cell lines.
    MS0621 interacts with a core complex of proteins that includes hnRNPH1, EWSR1, BRG1, and EWSR1::FLI1 in the absence of RNA or intact chromatin.
    hnRNPH1 knockdown recapitulates the effect of MS0621 on Ewing sarcoma cell proliferation.
    MS0621 affects EWSR1::FLI1-mediated gene expression and alternative splicing.
    MS0621 treatment recapitulated the effects of EWSR1::FLI1 loss on FAIRE, cell cycle, and gene expression through a mechanism independent of regulating EWSR1::FLI1 gene expression.
    MS0621 decreases FAIRE signal at EWSR1::FLI1-bound loci without displacing the oncoprotein from chromatin.

    物理化学性质&存储条件

    分子量 567.82
    分子式 C32H53N7O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(4-ethyl-1,4-diazepan-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine

    参考文献

    1. Tamara Vital, et al. Front Oncol. 2023 Jan 30;13:1099550.

    2. Cueva JP, et al. J Med Chem 58:4242–4249.

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