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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-MS049
MS049

Chemical Structure : MS049

CAS No.: 1502816-23-0

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MS049 (MS-049)

货号: PC-42113Not For Human Use, Lab Use Only.

MS049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50 of 34±10 nM and 43±7 nM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MS049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50 of 34±10 nM and 43±7 nM, respectively.
MS049 displays >30-fold and >300-fold selectivity over PRMT8 and PRMT1/3, does not inhibits PKMTs, DNMTases, RNA methyltransferases.
MS049 reduces the H3R2me2a mark in HEK293 cells with IC50 of 0.97 uM.

物理化学性质&存储条件

分子量 248.3639
分子式 C15H24N2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 31 mg/mL
Chemical Name/SMILES

1-Piperidineethanamine, N-methyl-4-(phenylmethoxy)-

参考文献

1. Shen Y, et al. J Med Chem. 2016 Oct 13;59(19):9124-9139.

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