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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-E3 Ubiquitin Ligase-MS.001
MS.001

Chemical Structure : MS.001

CAS No.: 53619-67-3

MS.001 (CHIP inhibitor MS001)

货号: PC-38239Not For Human Use, Lab Use Only.

MS.001 is a small molecule that inhibits both the chaperone binding and ubiquitin ligase activity of C-terminus of Hsc70 interacting protein (CHIP) at low micromolar concentrations (IC50=3.3 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MS.001 is a small molecule that inhibits both the chaperone binding and ubiquitin ligase activity of C-terminus of Hsc70 interacting protein (CHIP) at low micromolar concentrations (IC50=3.3 uM).
MS.001 also inhibits CHIP/chaperone interaction with IC50 of 3.8 uM.
MS.001 does not have activity against isolated U-box or tetratricopeptide (TPR) domains, but instead only inhibited full-length CHIP.

物理化学性质&存储条件

分子量 303.292
分子式 C13H9N3O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-nitro-7-(p-tolylsulfinyl)benzo[c][1,2,5]oxadiazole

参考文献

1. Kanack AJ, et al. Chembiochem. 2022 Mar 18;23(6):e202100633.

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