MS-453 |Cas:2059892-29-2 Buy MS-453 from ProbeChem, Global Biochemicals Supplier

Chemical Structure : MS-453

加入收藏

货号: PC-60300Not For Human Use, Lab Use Only.

MS-453 (MS453) is a potent, selective and covalent protein lysine methyltransferase SETD8 inhibitor with IC50 of 804 nM.

获取报价单

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

MS-453 (MS453) is a potent, selective and covalent protein lysine methyltransferase SETD8 inhibitor with IC50 of 804 nM.

MS-453 exhibits selectivity for SETD8 against 28 other methyltransferases.

MS-453 does not causes significant reduction in the H4K20me in HeLa cells at up to 10 uM.

MS-453 shows poor membrane permeability (4.4 nm/s) and high efflux ratio (137).

分子量	385.468
分子式	C20H27N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-((6,7-dimethoxy-2-(pyrrolidin-1-yl)quinazolin-4-yl)amino)propyl)acrylamide

1. Butler KV, et al. J Med Chem. 2016 Nov 10;59(21):9881-9889.