MS-444 (BE-34776) | HuR inhibitor | Probechem Biochemicals

Chemical Structure : MS-444

CAS No.: 150045-18-4

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MS-444 (BE-34776, MS444)

货号: PC-60907Not For Human Use, Lab Use Only.

MS-444 (BE-34776) is a small molecule inhibitor of RNA-binding protein Hu protein R (HuR) that interferes the HuR homodimerization with Kd of 7 nM.

规格	价格	库存
5 mg	￥3580	In stock
10 mg	￥5280	In stock
25 mg	￥8980	In stock
100 mg		Get quote

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生物&药学活性

MS-444 (BE-34776) is a small molecule inhibitor of RNA-binding protein Hu protein R (HuR) that interferes the HuR homodimerization with Kd of 7 nM.
MS-444 interferes with HuR RNA binding, HuR trafficking, cytokine expression and T-cell activation, and is a valuable tool for studying HuR function.
MS-444 augmentes DSS-induced weight loss and increases tumor multiplicity, size, and invasiveness in mice model of inflammatory colon cancer, also abrogates tumor cell apoptosis and depletes tumor-associated eosinophils, accompanied by a decrease in IL18 and eotaxin-1.

物理化学性质&存储条件

分子量	230.21
分子式	C13H10O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,8-Dihydroxy-3-methyl-naphtho[2,3-c]furan-4(9H)-one

参考文献

1. Meisner NC, et al. Nat Chem Biol. 2007 Aug;3(8):508-15.

2. Blanco FF, et al. Oncotarget. 2016 Nov 8;7(45):74043-74058.

3. Lang M, et al. Cancer Res. 2017 May 1;77(9):2424-2438.

MS-444 (BE-34776, MS444)

生物&药学活性

物理化学性质&存储条件

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MS-444 (BE-34776, MS444)

生物&药学活性

物理化学性质&存储条件

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