MRV03-069

Chemical Structure : MRV03-069

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货号: PC-49388Not For Human Use, Lab Use Only.

MRV03-069 is a small molecule compound that potently and specifically inhibit the colibactin-activating peptidase ClbP (IC50=28 nM), inhibits colibactin-associated genotoxicity.

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生物&药学活性

MRV03-069 is a small molecule compound that potently and specifically inhibit the colibactin-activating peptidase ClbP (IC50=28 nM), inhibits colibactin-associated genotoxicity.
MRV03-069 does not appear to interact with any of the other serine hydrolases.
MRV03-069 engages the ClbP binding pocket, forming a covalent bond with the catalytic serine.
MRV03-069 could reproduce the phenotypes observed in a clbP deletion mutant and block the genotoxic effects of colibactin on eukaryotic cells.
MRV03-069 also inhibits purified ZmaM with similar potency to ClbP in vitro, a ClbP homolog that is proposed to activate the antibiotic zwittermicin.

物理化学性质&存储条件

分子量	278.115
分子式	C13H19BN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-(3-amino-3-oxo-1-(4-phenylbutanamido)propyl)boronic acid

参考文献

1. Volpe MR, et al. Nat Chem Biol. 2022 Oct 17. doi: 10.1038/s41589-022-01147-8.

MRV03-069

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MRV03-069

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物理化学性质&存储条件

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