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首页-小分子抑制剂&激动剂-Autophagy-ULK-MRT68921 hydrochloride
MRT68921 hydrochloride

Chemical Structure : MRT68921 hydrochloride

CAS No.: 2080306-21-2

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MRT68921 hydrochloride (MRT-68921 hydrochloride)

货号: PC-42021Not For Human Use, Lab Use Only.

MRT-68921 hydrochloride (MRT68921) is a potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively.

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10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MRT68921 hydrochloride (MRT68921) is a potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively.
MRT-68921 hydrochloride inhibits a number of kinases by over 80% in a broad panel of 80 protein kinases, including TBK1 and AMPK.
MRT-68921 hydrochloride reduces phospho-ATG13 and blocks autophagy in cells.

物理化学性质&存储条件

分子量 471.038
分子式 C25H35ClN6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

H2O: 10 mg/mL
Chemical Name/SMILES

Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-,hydrochloride (1:2)

参考文献

1. Petherick KJ, et al. J Biol Chem. 2015 May 1;290(18):11376-83.

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