MRT-92 | Smoothened inhibitor | Probechem Biochemicals

Chemical Structure : MRT-92

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MRT-92 (MRT92)

货号: PC-20089Not For Human Use, Lab Use Only.

MRT-92 is a potent selective Smoothened (Smo) receptor antagonist (Kd=0.3 nM), inhibits rodent cerebellar granule cell proliferation induced by Hh pathway activation with IC50 of 0.4 nM.

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生物&药学活性

MRT-92 is a potent selective Smoothened (Smo) receptor antagonist (Kd=0.3 nM), inhibits rodent cerebellar granule cell proliferation induced by Hh pathway activation with IC50 of 0.4 nM.
MRT-92 blocked both SAG (0.1 µM) and GSA-10 (1 µM) induced differentiation of C3H10T1/2 cells with IC50 of 0.006 and 1 uM, respectively.
MRT-92 displayed an IC50 of 5.6 nM for SAG induction of AP response, selectively blocks SmoSAG-induced AP response in C3H10T1/2 cells.
MRT-92 abrogated Smo ciliary translocation promoted by SAG in primary cilium of NIH3T3 cells.
MRT-92 did not block Wnt signaling.
MRT-92 inhibited rat GCPs and Shh medulloblastoma cell proliferation.

物理化学性质&存储条件

分子量	566.66
分子式	C33H34N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,4,5-trimethoxy-N-(N-(4-methyl-3-(4-phenethylbenzamido)phenyl)carbamimidoyl)benzamide

参考文献

1. Lucile Hoch, et al. FASEB J. 2015 May;29(5):1817-29.

MRT-92 (MRT92)

生物&药学活性

物理化学性质&存储条件

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MRT-92 (MRT92)

生物&药学活性

物理化学性质&存储条件

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