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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Smoothened (Smo)-MRT-83
MRT-83

Chemical Structure : MRT-83

CAS No.: 1263131-92-5

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MRT-83 (MRT83)

货号: PC-62173Not For Human Use, Lab Use Only.

MRT-83 is a potent Smoothened antagonist that blocks Hedgehog (Hh) signaling in various assays with IC50 of 10 nM.

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5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥4280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MRT-83 is a potent Smoothened antagonist that blocks Hedgehog (Hh) signaling in various assays with IC50 of 10 nM.
MRT-83 inhibits Bodipy-cyclopamine binding to human and mouse Smo but does not modify Wnt signaling, blocks BC binding to HEK-hSmo cells with IC50 of 4.6 nM.
MRT-83 abrogates the agonist-induced trafficking of endogenous mouse or human Smo, efficiently antagonizes Hh signaling in vivo.

物理化学性质&存储条件

分子量 538.604
分子式 C31H30N4O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-methyl-5-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)-[1,1'-biphenyl]-4-carboxamide

参考文献

1. Roudaut H, et al. Mol Pharmacol. 2011 Mar;79(3):453-60.

2. Solinas A, et al. J Med Chem. 2012 Feb 23;55(4):1559-71.

3. Lauressergues E, et al. Pharmacol Res Perspect. 2016 Mar 4;4(2):e00214.

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