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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-BCRP-MRS8431
MRS8431

Chemical Structure : MRS8431

CAS No.:

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MRS8431 (MRS-8431)

货号: PC-26268Not For Human Use, Lab Use Only.

MRS8431 is a specific inhibitor of ABCG2 (breast cancer resistance protein, BCRP) ATPase activity with IC50 of 160 nM, inhibits ABCG2-mediated substrate transport with marginal effects on the activity of P-gp, sensitizes ABCG2-expressing HEK-293-R5 cells to mitoxantrone.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MRS8431 is a specific inhibitor of ABCG2 (breast cancer resistance protein, BCRP) ATPase activity with IC50 of 160 nM, inhibits ABCG2-mediated substrate transport with marginal effects on the activity of P-gp, sensitizes ABCG2-expressing HEK-293-R5 cells to mitoxantrone.

物理化学性质&存储条件

分子量 708.13
分子式 C36H28ClF2N9O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1S,2R,3S,4R,5S)-4-(6-((4-(4-(4-Chlorophenyl)-1H-1,2,3-triazol-1-yl)­benzyl)­amino)-2-((3,4-difluorophenyl)­ethynyl)-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo­[3.1.0]­hexane-1-carboxamide

参考文献

1. Murakami M, et al. J Med Chem. 2026 Feb 26;69(4):4945-4968.

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