MRS4833 | P2Y14 inhibitor | Probechem Biochemicals

Chemical Structure : MRS4833

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MRS4833 (MRS-4833)

货号: PC-20962Not For Human Use, Lab Use Only.

MRS4833 is a potent, selective antagonist of Gi protein-coupled P2Y14 receptor (P2Y14R, GPR105) with IC50 of 5.9 nM, Ki of 3.44 nM (human P2Y14R).

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生物&药学活性

MRS4833 is a potent, selective antagonist of Gi protein-coupled P2Y14 receptor (P2Y14R, GPR105) with IC50 of 5.9 nM, Ki of 3.44 nM (human P2Y14R).
MRS4833 shows an IC50 of 4.8 nM for mouse P2Y14R.
MRS4833 reduced airway eosinophilia in a protease-mediated asthma model.

物理化学性质&存储条件

分子量	503.52
分子式	C30H24F3NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(O)C1=CC(C2=CC=C([C@@]3(O)[C@]4([H])CNC[C@@]3([H])C4)C=C2)=C5C=CC(C6=CC=C(C(F)(F)F)C=C6)=CC5=C1

参考文献

1. Zhiwei Wen, et al. J Med Chem. 2023 Jul 13;66(13):9076-9094.

MRS4833 (MRS-4833)

生物&药学活性

物理化学性质&存储条件

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MRS4833 (MRS-4833)

生物&药学活性

物理化学性质&存储条件

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