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首页-小分子抑制剂&激动剂-GPCR-P2Y Receptor-MRS4654
MRS4654

Chemical Structure : MRS4654

CAS No.: 2765570-58-7

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MRS4654 (MRS-4654)

货号: PC-20961Not For Human Use, Lab Use Only.

MRS4654 is a potent, selective antagonist of Gi protein-coupled P2Y14 receptor (P2Y14R, GPR105) with IC50 of 15 nM and 18.6 nM for human and rat P2Y14R, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MRS4654 is a potent, selective antagonist of Gi protein-coupled P2Y14 receptor (P2Y14R, GPR105) with IC50 of 15 nM and 18.6 nM for human and rat P2Y14R, respectively.
MRS4654 (10 μmol/kg, i.p.) reversed CCI-induced mechano-allodynia in mouse model of neuropathic pain caused by chronic constriction of the sciatic nerve.

物理化学性质&存储条件

分子量 489.45
分子式 C28H18F3NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(O)C1=CC(C2=CC=C(C3=NOC(CO)=C3)C=C2)=C4C=CC(C5=CC=C(C(F)(F)F)C=C5)=CC4=C1

参考文献

1. Young-Hwan Jung, et al. J Med Chem. 2021 Apr 22;64(8):5099-5122.

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