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首页-小分子抑制剂&激动剂-GPCR-P2Y Receptor-MRS4608
MRS4608

Chemical Structure : MRS4608

CAS No.: 2370976-04-6

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MRS4608 (MRS-4608)

货号: PC-20959Not For Human Use, Lab Use Only.

MRS4608 is a potent, selective antagonist of Gi protein-coupled P2Y14 receptor (P2Y14R, GPR105) with IC50 of 6.32 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MRS4608 is a potent, selective antagonist of Gi protein-coupled P2Y14 receptor (P2Y14R, GPR105) with IC50 of 6.32 nM.
MRS4608 (10 mg/kg) protected in an ovalbumin/Aspergillus mouse asthma model.

物理化学性质&存储条件

分子量 501.55
分子式 C31H26F3NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(O)C1=CC(C2=CC=C(C3(CC4)CCN4CC3)C=C2)=C5C=CC(C6=CC=C(C(F)(F)F)C=C6)=CC5=C1

参考文献

1. Young-Hwan Jung, et al. J Med Chem. 2020 Sep 10;63(17):9563-9589.

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