MRS2578 | P2Y6 antagonist | Probechem Biochemicals

Chemical Structure : MRS2578

CAS No.: 711019-86-2

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MRS2578 (MRS-2578, MRS 2578)

货号: PC-43381Not For Human Use, Lab Use Only.

MRS2578 is a potent, selective P2Y6 receptor antagonist with IC50 of 37 nM (human) and 101 nM (rat).

规格	价格	库存
10 mg	￥480	In stock
25 mg	￥780	In stock
50 mg	￥1280	In stock
100 mg	￥2180	In stock
250 mg		Get quote

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生物&药学活性

MRS2578 is a potent, selective P2Y6 receptor antagonist with IC50 of 37 nM (human) and 101 nM (rat).
MRS2578 inhibits the response to 300 nM UDP at the rat P2Y6 receptor expressed in 1321N1 cells in a concentration-dependent manner, with IC50 values of 101 ± 27 nM and 98 ± 11 nM, respectively.
MRS2578 does not affect the UTP (100 nM)-induced responses of cells expressing P2Y2 and P2Y4 receptors as well as P2Y1 and P2Y11 receptor.
MRS2578 completely blocks the protection by UDP of cells undergoing TNFα-induced apoptosis at 1 uM.
MRS2578 bolcks ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation.

物理化学性质&存储条件

分子量	472.673
分子式	C20H20N6S4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 80 mg/mL
Chemical Name/SMILES	Thiourea, N,N''-1,4-butanediylbis[N'-(3-isothiocyanatophenyl)- (9CI)

参考文献

1. Talasila A, et al. Br J Pharmacol. 2009 Sep;158(1):339-53.

2. Mamedova LK, et al. Biochem Pharmacol. 2004 May 1;67(9):1763-70.

3. Wihlborg AK, et al. Circ Res. 2006 Apr 14;98(7):970-6.

4. Mamedova LK, et al. Pharmacol Res. 2008 Sep-Oct;58(3-4):232-9.

MRS2578 (MRS-2578, MRS 2578)

生物&药学活性

物理化学性质&存储条件

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MRS2578 (MRS-2578, MRS 2578)

生物&药学活性

物理化学性质&存储条件

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