MRS2481 |CAS:859724-30-4 Probechem Biochemicals

Chemical Structure : MRS2481

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MRS2481 (MRS-2481)

货号: PC-62066Not For Human Use, Lab Use Only.

MRS 2481 is a potent, reversible Aβ42 neurotoxicity inhibitor with ID50 of 500 nM, potently blocks the Aβ calcium channel and protects neurons from Aβ toxicity.

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生物&药学活性

MRS 2481 is a potent, reversible Aβ42 neurotoxicity inhibitor with ID50 of 500 nM, potently blocks the Aβ calcium channel and protects neurons from Aβ toxicity.
MRS 2481 also is a potent inhibitor of TNFα-induced phosphorylation and proteosomal destruction of IκBα, inhibits both NFκB and AP-1 signaling on the IL-8 promoter (IC50=1.8 uM).
MRS 2481 blocks TNFα-activated phosphorylation of JNK, the c-JUN kinase.

物理化学性质&存储条件

分子量	420.391
分子式	C22H30BrNO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(8-((2-phenylpropanoyl)oxy)octyl)pyridin-1-ium bromide

参考文献

1. Diaz JC, et al. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3348-53.

2. Tchilibon S, et al. Biochem Pharmacol. 2005 Aug 1;70(3):381-93.

MRS2481 (MRS-2481)

生物&药学活性

物理化学性质&存储条件

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MRS2481 (MRS-2481)

生物&药学活性

物理化学性质&存储条件

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