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首页-小分子抑制剂&激动剂-GPCR-P2Y Receptor-MRS2179 tetrasodium
MRS2179 tetrasodium

Chemical Structure : MRS2179 tetrasodium

CAS No.: 1454889-37-2

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MRS2179 tetrasodium (MRS-2179 tetrasodium)

货号: PC-61744Not For Human Use, Lab Use Only.

MRS 2179 is a potent, selective, competitive P2Y1 receptor antagonist with Kb of 100 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MRS2179 is a potent, selective, competitive P2Y1 receptor antagonist with Kb of 100 nM.
    MRS2179 displays no appreciable activity at P2Y2, P2Y4, or P2Y6 receptors (>30 uM).
    MRS2179 inhibits ADP-induced platelet shape change, aggregation and Ca2+ rise but has no effect on ADP-induced inhibition of adenylyl cyclase.
    MRS2179 decreases platelet count in mice.

    物理化学性质&存储条件

    分子量 513.16
    分子式 C11H13N5O9P2Na4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2'-Deoxy-N6-methyladenosine 3',5'-bisphosphate tetrasodium salt

    参考文献

    1. Moro S, et al. J Med Chem. 1998 Apr 23;41(9):1456-66.

    2. Baurand A, et al. Eur J Pharmacol. 2001 Feb 2;412(3):213-21.

    3. Léon C, et al. Circulation. 2001 Feb 6;103(5):718-23.

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