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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Calcium Channel -MRS1845
MRS1845

Chemical Structure : MRS1845

CAS No.: 544478-19-5

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MRS1845 (N-propargyl-nitrendipine)

货号: PC-22078Not For Human Use, Lab Use Only.

MRS1845 is a selective store-operated Ca2+ channel (SOC) Orai1 inhibitor, inhibits SOC channel-dependent elevations of calcium with IC50 of 1.7 uM in HL-60 cells.

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5 mg ￥1180 In stock
10 mg ￥1780 In stock
25 mg ￥2980 In stock
50 mg ￥4980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MRS1845 is a selective store-operated Ca2+ channel (SOC) Orai1 inhibitor, inhibits SOC channel-dependent elevations of calcium with IC50 of 1.7 uM in HL-60 cells.
MRS1845 attenuates neutrophil function and postshock acute lung injury.

物理化学性质&存储条件

分子量 398.42
分子式 C21H22N2O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1-(prop-2-yn-1-yl)-1,4-dihydropyridine-3,5-dicarboxylate

参考文献

1. Harper JL, et al. Biochem Pharmacol. 2003 Feb 1;65(3):329-38.

2. Cindy Lee, et al. J Trauma. 2005 Jul;59(1):56-63; discussion 63.

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