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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-MRS 1477
MRS 1477

Chemical Structure : MRS 1477

CAS No.: 212200-21-0

MRS 1477 (MRS1477;MRS-1477)

货号: PC-60668Not For Human Use, Lab Use Only.

MRS 1477 is a small molecule positive allosteric modulator of both proton and vanilloid activation of TRPV1 (EC50=21.3 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MRS 1477 is a small molecule positive allosteric modulator of both proton and vanilloid activation of TRPV1 (EC50=21.3 uM).
    MRS 1477 increases sensitivity of already sensitized TPRV1 toward capsaicin, does not affect inhibition by capsazepine or ruthenium red and remains effective in potentiating activation by pH in the presence of an orthosteric vanilloid antagonist.

    物理化学性质&存储条件

    分子量 389.51
    分子式 C21H27NO4S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    4,5-diethyl-3-(2-methoxyethylthio)-2-methyl-6-phenyl-1,4-(±)-dihydropyridine-3,5-dicarboxylate

    参考文献

    1. Kaszas K, et al. J Pharmacol Exp Ther. 2012 Jan;340(1):152-60.

    2. Lebovitz EE, et al. Mol Pain. 2012 Sep 21;8:70.

    3. Nazıroğlu M, et al. PLoS One. 2017 Jun 22;12(6):e0179950.

    4. Roh EJ, et al. Bioorg Med Chem. 2008 Oct 15;16(20):9349-58.

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