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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-PPAR-MRL20
MRL20

Chemical Structure : MRL20

CAS No.: 393794-32-6

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MRL20 (MRL 20)

货号: PC-62345Not For Human Use, Lab Use Only.

MRL20 is a novel synthetic PPARγ ligand and orthosteric agonist with canonical LBP binding affinity of 2 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MRL20 is a novel synthetic PPARγ ligand and orthosteric agonist with canonical LBP binding affinity of 2 nM.
    MRL20 can bind to the alternate site of PPARγ covalently bound to an endogenous ligand, increases TRAP220 binding and decreases NCoR binding to 15-oxoETE bound PPARγ with EC50 of 20-30 uM.

    物理化学性质&存储条件

    分子量 527.496
    分子式 C28H24F3NO6
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2S)-2-[2-[[1-(4-Methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl]methyl]phenoxy]propanoic acid

    参考文献

    1. Hughes TS, et al. Nat Commun. 2014 Apr 7;5:3571. doi: 10.1038/ncomms4571.

    2. Brust R, et al. ACS Chem Biol. 2017 Apr 21;12(4):969-978.

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