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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-ROR-MRL-871
MRL-871

Chemical Structure : MRL-871

CAS No.: 1392809-08-3

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MRL-871 (MRL871)

货号: PC-35406Not For Human Use, Lab Use Only.

MRL-871 (MRL871) is a potent, selective inhibitor of RORγt via allosteric inverse agonism, inhibits coactivator binding with IC50 of 7 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MRL-871 (MRL871) is a potent, selective inhibitor of RORγt via allosteric inverse agonism, inhibits coactivator binding with IC50 of 7 nM.
    MRL-871 significantly reduces the IL17a mRNA levels in EL4 murine lymphoblast cell line at 10 uM.

    物理化学性质&存储条件

    分子量 444.794
    分子式 C22H12ClF3N2O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)benzoic acid

    参考文献

    1. Scheepstra M, et al. Nat Commun. 2015 Dec 7;6:8833.

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